Kininesulfaat 3x 250 mg per dag (gedurende 3 weken). Is dit geen te hoge dosis?

Aangezien er geen indicatie gekend is en er in de literatuur nog hogere dossissen beschreven staan, lijkt dit geen ongewone dosering.

Martindale beschrijft:

“Quinine is given as a number of salts and 100 mg of anhydrous quinine is equivalent to about: […] 121 mg of quinine sulfate.
[…]
A course of treatment with quinine for falciparum malaria usually lasts 7 days and in uncomplicated infections treatment should preferably be given by the oral route. The usual oral dose is 600 mg of quinine salt given every 8 hours for 7 days. For children, a dose of 10 mg of quinine salt per kg body-weight given every 8 hours for 7 days is recommended.
[…]
When used for the relief of nocturnal leg cramps, quinine is given at night in an oral dose of 200 to 300 mg of the sulfate or bisulfate”

Type: Informatief
Grondstof: Kininesulfaat
CNK: 0252031, 0252049, 0252056, en 4120812