Vanaf welk gehalte alkaloïden is ipeca braakopwekkend?

In de Martindale wordt volgende informatie teruggevonden in verband met ipeca: “Ipecacuanha has been used as an expectorant in productive cough in doses of up to about 1,4 mg of total alkaloids. Ipecacuanha may also be used in larger doses as an emetic but is of very limited value. Vomiting ususally occurs within 30 minutes of an oral emetic dose, due to an irritant effect on the gastrointestinal tract and a central action on the chemorceptor trigger zone. Doses are usually followed by a copious drink of water or fruit juice. Adults have been given doses of about 21 to 42 mg of total alkaloids; each 5 mL of Ipecac. syrup (USP 31) supplies about 7 mg of total alkaloids. Doses may be repeated once only after 20 to 30 minutes if emesis has not been occured”