Er dient rekening gehouden te worden met het verschil in moleculaire gewichten tussen codeine base monohydraat en codeinefosfaat. Volgens Martindale:
– MG codeine monohydraat: 317.4g/mol
– MG codeine fosfaat hemihydraat: 406.4g/mol
Codeïnefosfaat kent een breder toepassingsgebied dan codeïne. Bespreek een mogelijke switch met de voorschrijvende arts.
Martindale geeft volgende informatie betreffende toepassingsgebieden:
“Codeine or its salts, especially the phosphate, are given orally in the form of linctuses for the relief of cough, and as tablets for the relief of mild to moderate pain, often with a non-opioid analgesic such as aspirin, ibuprofen, or paracetamol. The phosphate is also given by intramuscular or subcutaneous injection, in doses similar to those used orally, for the relief of pain; the intravenous and rectal routes have also been used. For the relief of pain codeine phosphate may be given in doses of 30 to 60 mg every 4 hours to a usual maximum of 240 mg daily.
To allay non-productive cough codeine phosphate maybe given in doses of 15 to 30 mg three or four times
daily.
Codeine phosphate is also used as tablets or in mixtures for the symptomatic relief of acute diarrhoea in doses
of 15 to 60 mg given 3 or 4 times daily”
