{"id":49244,"date":"2024-09-10T15:11:26","date_gmt":"2024-09-10T13:11:26","guid":{"rendered":"https:\/\/fagroncompoundingservices.be\/qanda\/comment-preparer-une-creme-ou-un-gel-avec-du-citrate-de-sildenafil\/"},"modified":"2024-09-10T15:11:26","modified_gmt":"2024-09-10T13:11:26","slug":"comment-preparer-une-creme-ou-un-gel-avec-du-citrate-de-sildenafil","status":"publish","type":"qanda","link":"https:\/\/fagroncompoundingservices.be\/fr\/qanda\/comment-preparer-une-creme-ou-un-gel-avec-du-citrate-de-sildenafil\/","title":{"rendered":"Comment dois-je pr\u00e9parer une cr\u00e8me ou un gel avec du sild\u00e9nafil (citrate de) ?"},"content":{"rendered":"<p>Le DAC\/NRF fournit plus d\u2019informations sur l\u2019utilisation cutan\u00e9e du citrate de sild\u00e9nafil. \u00ab\u00a0For the treatment of erectile dysfunction in men, semi-solid preparations are being used on a trial basis abroad to achieve a local effect. For women, regulations for so-called \u00ab\u00a0libido creams\u00a0\u00bb have been published abroad (7).\u00bb Si la cr\u00e8me ou le gel doit \u00eatre administr\u00e9 par voie vaginale, le DAC\/NRF fournit les informations suivantes : \u00ab Sildenafil citrate is said to contribute to improved uterine blood flow and to the development of the uterine lining during in vitro fertilization (3, 5).\u00bb Pour les deux applications, une cr\u00e8me et un gel \u00e0 1% sont discut\u00e9s. Comme base d\u2019une cr\u00e8me, une cr\u00e8me H\/E est propos\u00e9e, par exemple une cr\u00e8me tamponn\u00e9e au c\u00e9tomacrogol. Cependant, sa dur\u00e9e de conservation est limit\u00e9e : 14 jours au r\u00e9frig\u00e9rateur. La solubilit\u00e9 dans l\u2019eau du citrate de sild\u00e9nafil n\u2019est pas particuli\u00e8rement \u00e9lev\u00e9e. Le propyl\u00e8ne glycol peut \u00eatre utilis\u00e9 comme cosolvant. Le gel \u00e0 1 % est d\u00e9crit comme suit : 2 % de m\u00e9thylcellulose 4000 avec du propyl\u00e8ne glycol (+\/- 10 mL) servant \u00e0 nouveau de cosolvant. En Belgique, 400 mPas ou 1500 mPas sont commercialis\u00e9s. Pour obtenir une viscosit\u00e9 similaire, il faudra utiliser une concentration sup\u00e9rieure aux 2 % d\u00e9crits.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_cat":[64],"faq-type":[2790],"grondstof":[3069],"qanda-related":[],"cnk":[3067,3065],"qanda-similar":[],"class_list":["post-49244","qanda","type-qanda","status-publish","hentry","product_cat-preparations-semi-solides","faq-type-question-de-preparation","grondstof-citrate-de-sildenafil","cnk-3090263-fr","cnk-4764296-fr"],"acf":[],"_links":{"self":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda\/49244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda"}],"about":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/types\/qanda"}],"wp:attachment":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/media?parent=49244"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/product_cat?post=49244"},{"taxonomy":"faq-type","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/faq-type?post=49244"},{"taxonomy":"grondstof","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/grondstof?post=49244"},{"taxonomy":"qanda-related","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda-related?post=49244"},{"taxonomy":"cnk","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/cnk?post=49244"},{"taxonomy":"qanda-similar","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda-similar?post=49244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}