{"id":48481,"date":"2024-09-05T09:59:43","date_gmt":"2024-09-05T07:59:43","guid":{"rendered":"https:\/\/fagroncompoundingservices.be\/qanda\/le-metronidazole-et-lerythromycine-dans-une-base-de-creme-peuvent-etre-traites\/"},"modified":"2024-09-05T09:59:43","modified_gmt":"2024-09-05T07:59:43","slug":"le-metronidazole-et-lerythromycine-dans-une-base-de-creme-peuvent-etre-traites","status":"publish","type":"qanda","link":"https:\/\/fagroncompoundingservices.be\/fr\/qanda\/le-metronidazole-et-lerythromycine-dans-une-base-de-creme-peuvent-etre-traites\/","title":{"rendered":"Le m\u00e9tronidazole et l\u2019\u00e9rythromycine peuvent-ils \u00eatre utilis\u00e9s dans une seule base de cr\u00e8me ?"},"content":{"rendered":"<p>Les plages de pH stables des deux actifs devront \u00eatre prises en compte.<br \/>\nL\u2019\u00e9rythromycine est stable dans une plage de pH comprise entre 6 et 9,5.<br \/>\nLe m\u00e9tronidazole est stable dans une plage de pH comprise entre 4 et 6.<br \/>\nAjuster le pH \u00e0 6,3 avec du NaOH permettrait d\u2019incorporer les deux actifs dans une seule base de cr\u00e8me.<br \/>\nTrissels dispose d\u2019une \u00e9tude dans laquelle l\u2019\u00e9rythromycine dans une \u00e9mulsion H\/E avec un pH de 6,3 reste stable \u00e0 temp\u00e9rature ambiante pendant 12 mois.<br \/>\n(Tissel, L.A., Stabilit\u00e9 des formulations compos\u00e9es. 5e \u00e9d., Washington DC : American Pharmacists Association, 2012.p.190-191)     <\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_cat":[64],"faq-type":[2790],"grondstof":[2808],"qanda-related":[3662,2965],"cnk":[4497,4499,4501],"qanda-similar":[2810],"class_list":["post-48481","qanda","type-qanda","status-publish","hentry","product_cat-preparations-semi-solides","faq-type-question-de-preparation","grondstof-erythromycine-fr","qanda-related-creme-de-cetomacrogol-non-tamponnee","qanda-related-metronidasole","cnk-0486985-fr","cnk-0486993-fr","cnk-0487009-fr","qanda-similar-erythromycine-fr"],"acf":[],"_links":{"self":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda\/48481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda"}],"about":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/types\/qanda"}],"wp:attachment":[{"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/media?parent=48481"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/product_cat?post=48481"},{"taxonomy":"faq-type","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/faq-type?post=48481"},{"taxonomy":"grondstof","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/grondstof?post=48481"},{"taxonomy":"qanda-related","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda-related?post=48481"},{"taxonomy":"cnk","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/cnk?post=48481"},{"taxonomy":"qanda-similar","embeddable":true,"href":"https:\/\/fagroncompoundingservices.be\/fr\/wp-json\/wp\/v2\/qanda-similar?post=48481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}