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De Martindale geeft alvast volgende informatie mee:
“Phosphates are used in the management of hypophosphataemia caused by phosphate deficiency or hypophosphataemic states. Doses of up to 100 mmol of phosphate daily may be given orally.
The intravenous route is seldom necessary, but a dose of up to 9 mmol of phosphate as monobasic potassium phosphate may be given over 12 hours and repeated every 12 hours as necessary for severe hypophosphataemia.
Alternatively, 0.2 to 0.5 mmol/kg phosphate, up to a maximum of 50 mmol, may be given over 6 to 12 hours (see also below). Plasma-electrolyte concentrations, especially phosphate and calcium, and renal function should be carefully monitored. Reduced doses may be necessary in patients with renal impairment.
Phosphate supplements are used in total parenteral nutrition regimens; typical daily requirements are 20 to 30 mmol of phosphate. Phosphates act as mild osmotic laxatives when given orally as dilute solutions or by the rectal route. Phosphate enemas or concentrated oral solutions are used for bowel cleansing before surgery or endoscopy procedures. Preparations typically combine monobasic and dibasic sodium phosphates but the composition and dosage do vary slightly. Phosphate enemas act within 2 to 5 minutes, whereas the oral solutions act within 30 minutes to 6 hours.
Phosphates also have other uses. They lower the pH of urine and have been given as adjuncts to urinary antibacterials that depend on an acid urine for their activity. Phosphates have also been used for the prophylaxis of calcium renal calculi; the phosphates reduce urinary excretion of calcium thus preventing calcium deposition. A suggested oral dose for both uses is 7.4 mmol of phosphate four times daily. Oral phosphates may be used to prevent gastrointestinal absorption of calcium in the treatment of hypercalcaemia. The dose in adults is up to 100 mmol phosphate daily adjusted according to response”