CNK: 0256891

Kan macrogol (400 / 4000) inwendig gebruikt worden?

Macrogol 400 (Peg) & macrogol 4000 (Peg) zijn geschikt voor inwendig gebruik en kent onder meer toepassingen als laxativum.
Martindale beschrijft:
Uses and Administration
Macrogols are relatively stable, non-toxic compounds which have a range of properties depending on their molecular weight. They are widely used in pharmaceutical manufacturing as watersoluble bases for topical preparations and suppositories, as solvents and vehicles, and as solubilising agents, tablet binders, plasticisers in film coating, and tablet lubricants. They have also been reported to have antibacterial properties. Macrogols of high molecular weight such as macrogol 4000 have been used as inert markers in studies on intestinal absorption and excretion.
A mixture of macrogol 3350 or 4000 with electrolytes is used for bowel preparation before colonoscopy, radiological procedures, or surgery. […]
Similar preparations are used in patients 12 years of age and over for the treatment of chronic constipation in a usual dose of 125 mL of a solution containing 105 g of the macrogol per litre, up to three times daily. […]
In the management of faecal impaction, 8 doses of 125 mL of solution should be consumed within 6 hours for a maximum of 3 days. […]

Kan ik Movicol namaken?

Samenstelling per zakje Movicol (zie bijsluiter):

Macrogol 3350 13,125 g
Natriumchloride 0,3507 g
Natriumwaterstofcarbonaat 0,1785 g
Kaliumchloride 0,0466 g

Na oplossen van 1 zakje in 125 ml water, bevat deze oplossing de volgende
elektrolyten:
Natrium: 65 mmol/l
Chloride 53 mmol/l
Kalium 5,4 mmol/l
Bicarbonaat 17 mmol/l

Voor de volledige lijst van hulpstoffen, zie rubriek 6.1.

6.1 Lijst van hulpstoffen Kalium acesulfaam (E950) Citroen- en limoenaroma* (*Citroen- en limoenaroma bevat de volgende bestanddelen: arabische gom, maltodextrine, limoenolie, citroenolie, citral, citroenzuur en water)

https://www.bcfi.be/nl/chapters/4?frag=3111&trade_family=17822%20zie%20BCFI

Als alternatief voor macrogol 3350 kan macrogol 4000 gebruikt worden, mits omrekening aan de hand van de regel van drie.